List of drug master files dmf of allopurinol active pharmaceutical ingredient api submitted to the u. Allopurinol definition of allopurinol by medical dictionary. Xo also plays an important role in free radical generation during skeletal. Allopurinol, sold under the brand name zyloprim among others, is a medication used to decrease high blood uric acid levels. Zyloprim allopurinol dose, indications, adverse effects. Reports indicate that allopurinol and oxipurinol are excreted in human breast milk. Pdf desensibilizacion a alopurinol en paciente con gota tofacea. Laboratory assessment of liver function is recommended at, for example, 2 and 4 months following initiation of uloric and periodically thereafter. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pdf effects of allopurinol on exerciseinduced muscle. Allopurinol is considered the firstline uratelowering medicine, unless there is a history of allergy or intolerance.
Xo also plays an important role in free radical generation during skeletal muscle. Pharmacokinetics and pharmacodynamics of allopurinol in. It is taken by mouth or injected into a vein common side effects when used by mouth include itchiness and rash. However, there are no data concerning the effects of allopurinol or its metabolites on breastfed babies. Myelosuppression can be exacerbated by coadministration with drugs that inhibit tpmt e. Hipersensibilidad al allopurinol, embarazo y lactancia. Allopurinol efectos secundarios, dosis, usos y mas 2020. Allopurinol and oxipurinol have been found in the milk of a mother who was receiving allopurinol.
Allopurinol hexal 300 mg tabletten medikamenteperklick. Alopurinol no debe ser administrado a individuos con hipersensibilidad conocida al. Avoid the concurrent use of allopurinol and purixan. If allopurinol is used in a breastfeeding mother, infants should be monitored. Allopurinol api dmfs us drug master file dmf details.
Concomitant allopurinol and purixan can result in a significant increase in bone marrow toxicity. Allopurinol is a xanthine oxidase inhibitor used in the. Allopurinol, a structural analogue of hypoxanthine, is used primarily in the treatment of hyperuricaemia and gout. Informate sobre efectos secundarios, dosis, precauciones y mas en medlineplus. It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. No doseeffect relationship for these transaminase elevations was noted. Since the effect of allopurinol on the breastfed infant is unknown, caution should be exercised when allopurinol is administered during breastfeeding.
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